In mild of such observations, sirtuins are recognised as novel regulators of immuno-metabolism in individuals. Other than SIRT1, SIRT2 has become not long ago linked to cytoskeleton remodeling and activation of NLRP3 in intracellular pathways[117]. In addition to the activation of innate immunity, the contribution of adaptive immune cells in https://www.directivepublications.org/journal-of-diabetology-research/