One example is, the diversion of methadone and buprenorphine from opioid agonist remedy is documented to generally be a significant challenge in a few countries (see Area Artificial opioid trafficking). Powerful artificial opioids, such as the fentanyl by-product carfentanil and benzimidazole (nitazene) opioids, eaten in the context of polydrug use, https://dutchcartel.eu/