Environmental or self-antigens and homotypic interactions induce BCR and Toll-like receptor (TLR) signaling, amplifying the response of CLL cells to other signals within the microenvironment and growing the activation of anti-apoptotic and proliferation pathways.31,32 Genomic scientific studies have recognized recurrent mutations in genes regulating tumor mobile-microenvironment inter... https://katex974ubj1.wikissl.com/user