In this article, we show that conolidine, a natural analgesic alkaloid used in traditional Chinese medication, targets ACKR3, thereby furnishing extra proof of the correlation involving ACKR3 and pain modulation and opening choice therapeutic avenues with the remedy of Serious agony. Tabernaemontana divaricata Conolidine can be an indole alkaloid. https://williamm837sro8.iamthewiki.com/user